Our Focus: The Maternal-Infant Axis
The gut microbiome plays a critical role in immune maturation and healthy development in the first years of life. Disruption of the microbiome, known as dysbiosis, leads to a multitude of diseases with life-long impacts. Leveraging this unique window of opportunity, Siolta is developing novel live biotherapeutic products designed to prevent and/or treat diseases in the “maternal-infant axis”.
The human microbiome plays a critical role in human health. Human clinical data suggests that the dysbiosis (the imbalance of microbial communities) of the microbiome can lead to the onset or recurrence of a wide range of diseases including allergic diseases, bacterial vaginosis (BV) and necrotizing enterocolitis (NEC). Our expertise in the infant gut microbiome has led to the development of STMC-103H for the prevention of atopic diseases in newborns. Given the strong scientific rationale supporting the use of live biotherapeutics, we have initiated two new multi-strain preclinical programs designed to prevent the recurrence of BV in women and to prevent and treat NEC, a rare pediatric disease, in preterm infants.
- Atopic Diseases
- Bacterial Vaginosis (BV)
- Necrotizing Enterocolitis
Atopic Diseases
Atopic diseases including atopic dermatitis, food allergy, and allergic asthma represent a global health problem that disproportionately impacts children. Surprisingly, there are no approved approaches to prevent the development of these diseases in at-risk individuals, resulting in chronic morbidity and economic burden. There is a crucial need to develop innovative strategies to prevent the onset of these Type 1 allergic diseases rather than treating their symptoms. A preventative approach targeting at-risk individuals could significantly reduce the morbidity and healthcare burden associated with these increasingly common conditions.
At Siolta Therapeutics we are leveraging our knowledge of the human microbiota’s impact on adaptive immune responses to develop novel live biotherapeutic products (LBPs) aimed at preventing and treating diseases with unmet medical needs. By applying our Precision Symbiotics Platform™, we develop LBPs composed of bacterial consortia to address the metabolic and immunological origins of disease. We pride ourselves on being one of the first microbiome medicines companies to move a mixed-species LBP into clinical development in the US.